Publications

J Carnevale, E Shifrut, N Kale, WA Nyberg, F Blaeschke, Y Chen, Z Li, SP Bapat, ME Diolaiti, P O’Leary, S Vedova, J Belk, B Daniel, TL Roth, S Bachl, AA Anido, D Haydar, M Luetke-Eversloh, M Born-Bony, B Hegde, S Kogan3, T Feuchtinger, H Okada, A Satpathy, K Shannon, S Gottschalk, J Eyquem, G Krenciute, Alan Ashworth, Alexander Marson. RASA2 ablation in T cells boosts antigen sensitivity and long-term function. Nature (2022).

JA Belk, W Yao, N Ly, KA Freitas, YT Chen, Q Shi, AM Valencia, E Shifrut, N Kale, KE Yost, CV Duffy, B Daniel, MA Hwee, Z Miao, A Ashworth, CL Mackall, A Marson, J Carnevale, SA Vardhana, AT Satpathy. Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence. Cancer Cell, (22):00231-8 (2022).

JR Byrnes, AM Weeks, E Shifrut, J Carnevale, L Kirkemo, A Ashworth, A Marson, JA Wells. Hypoxia Is a Dominant Remodeler of the Effector T Cell Surface Proteome Relative to Activation and Regulatory T Cell Suppression. Mol Cell Proteomics. (4):100217 (2022).

ES Tsang, EJ Walker, J Carnevale, GA Fisher, AH Ko. Durable response after immune checkpoint inhibitor-related diabetes in mismatch repair-deficient pancreatic cancer. Immunotherapy. (15):1249-1254 (2021).

SS Sinha, GC Greene, KR Kelley, CP Cinar, VA Venook, AC Atreya, GJ Gordan, J Carnevale, AM Anwar, FM Feng.. International Combined Immunotherapy and Hypofractionated Radiotherapy for Metastatic Cancers Journal of Radiation Oncology. (3):e648 (2020).

E Shifrut*, J Carnevale*, V Tobin, TL Roth, JM Woo, CT Bui, PJ Li, ME Diolaiti, A Ashworth, A Marson. Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function. Cell. (7):1958-1971 (2018). *authors contributed equally.

TL Roth, C Puig-Saus, R Yu, E Shifrut, J Carnevale, Li PJ, Hiatt J, Saco J, Krystofinski P, Li H, Tobin V, Nguyen DN, Lee MR, Putnam AL, Ferris AL, Chen JW, Schickel JN, Pellerin L, Carmody D, Alkorta-Aranburu G, Del Gaudio D, Matsumoto H, Morell M, Mao Y, Cho M, Quadros RM, Gurumurthy CB, Smith B, Haugwitz M, Hughes SH, Weissman JS, Schumann K, Esensten JH, May AP, Ashworth A, Kupfer GM, Greeley SAW, Bacchetta R, Meffre E, Roncarolo MG, Romberg N, Herold KC, Ribas A, Leonetti MD, Marson A. Reprogramming human T cell function and specificity with non-viral genome targeting. Nature. (7714):405-409 (2018).

J Carnevale, KA Ko. Targeting the Tumor Microenvironment. Current and Emerging Therapies in Pancreatic Cancer. 235-256 (2018).

J Carnevale, AH Ko. MM-398 (nanoliposomal irinotecan): emergence of a novel therapy for the treatment of advanced pancreatic cancer. Future Oncol. (4):453-64 (2016).

J Carnevale, JL Rubenstein. The Challenge of Primary Central Nervous System Lymphoma. Hematol Oncol Clin North Am. (6):1293-1316 (2016).

J Carnevale, A Ashworth. Assessing the Significance of BRCA1 and BRCA2 Mutations in Pancreatic Cancer. J Clin Oncol. (28):3080-1 (2015).

R Renella, J Carnevale, KA Schneider, JL Hornick, HQ Rana, KA Janeway. Exploring the association of succinate dehydrogenase complex mutations with lymphoid malignancies. Fam Cancer. (3):507-11 (2014).

J Carnevale, L Ross, A Puissant, V Banerji, RM Stone, DJ DeAngelo, KN Ross, K Stegmaier. SYK regulates mTOR signaling in AML. Leukemia. (11):2118-28 (2013).

News

Media highlights of Carnevale Lab's research.
Giving Immunotherapy Cells Resilience to Pass the “Stress Test”
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New Tool Opens Door to Next-Gen Targeted Immunotherapies
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New 'SLICE' tool can massively expand immune system's cancer-fighting repertoire
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Scientists discover how to prevent T cell exhaustion to maintain the fight against cancer
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Scientists Prevent “Exhaustion” in Cancer-Fighting T Cells
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